These chemical reactions form the basis for the synthesis of other biologically important derivatives such as tryptanthrin, indirubins, and 2-oxindoles. Isatin derivatives also have various industrial applications for example, they are used as corrosion inhibitors, as fluorescent sensors and also in the dye industry.
Isatin forms a blue dye (indophenin) if it is mixed with sulfuric acid and crude benzene. It is used as a reference material in the preparation of indigo and Maya Blue. It is also responsible for the yellow color exhibited by the "Maya Yellow" pigment.
Reactant for preparation of:
- Phthalazinone derivatives
- Spirooxindole derivatives
- Agents against multidrug-resistant cells expressing P-glycoprotein
- Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
- Triazole-isatine compounds as potential antibacterial and antifungal agents
- Biologically relevant scaffolds such as spiro[indole-thiazolidinones]
Reactant for:
- Cascade reactions with heterocyclic ketene aminals
- Knoevenagel condensation reactions
Administration of the compound with a single dose of 50 and 100 mg kg−1
