p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis.
p-Toluenesulfonic acid (PTSA or pTsOH) or tosylic acid (TsOH) is an organic compound with the formula CH3C6H4SO3H. It is a white solid that is soluble in water, alcohols, and other polar organic solvents.
p-Toluenesulfonic acid monohydrate was dried at 80 °C under high-vacuum for 48 h. Dry THF, toluene and CH2Cl2 were obtained by using a solvent drying system from Innovative Technologies.
TsOH is prepared on an industrial scale by the sulfonation of toluene. It is hygroscopic and hydrates readily. Common impurities include benzenesulfonic acid and sulfuric acid. TsOH monohydrate contains crystalline water as well as water as an impurity.
