Sodium benzoate (SB) is one of the most widely used additives in food products in the world. The aim of this study was to assess the effect of three different concentrations of SB on the DNA breakage in liver cells and on the micronuclei formation and the mitotic index in lymphocytes of pregnant rats and their fetuses, as well as to evaluate the effects of SB on the fetus development.
Sodium bisulfite solution may be used for the production of SO3- radicals, by reaction with OH in irradiated aqueous solutions containing N2O. Chemistry of these radicals has been investigated by pulse radiolysis with kinetic spectrophotometry.
initial dose ranges from 2.5 to 15 mcg/kg of body